DU145型
LNCaP公司
前列腺癌
癌症研究
癌变
SOX2
细胞生长
调节器
小RNA
生物
细胞培养
癌症
前列腺
细胞凋亡
转录因子
基因
遗传学
作者
Mustafa Özen,Ömer Faruk Karataş,Şükrü Güllüoğlu,Ömer Faruk Bayrak,Serhat Sevli,Esra Güzel,Işın Doğan Ekici,Turhan Çaşkurlu,Mustafa Solak,Chad J. Creighton,Michael Ittmann
标识
DOI:10.3109/07357907.2015.1025407
摘要
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.
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