Electrospun biodegradable nanofibers loaded with epigallocatechin gallate for guided bone regeneration

Guided bone regeneration through biomaterial-based formulations can prevent soft tissue migration into the bone defect area through a barrier membrane. However, bone regeneration requires bioactive external interference. Here, we report a biodegradable electrospun poly-l-lactic acid/gelatin-based nanofibrous membrane encapsulating epigallocatechin gallate (EGCG) within the core, with a smooth profile, desirable physicochemical properties, biocompatibility, antibacterial effects, sufficient osteoinductive capability, and sustained EGCG release over one week. 70% of the defect area was repaired with the help of the EGCG-loaded membrane, approximately 1.5-fold improvement over the control group in 8 weeks. In conclusion, these membranes are promising candidates for guided bone regeneration.