Long-term outcomes of patients with acromegaly: a report from the Swedish Pituitary Register

肢端肥大症 医学 垂体瘤 内科学 入射(几何) 放射治疗 儿科 激素 生长激素 内分泌学 光学 物理
作者
Steinunn Arnardóttir,Jacob Järås,Pia Burman,Katarina Berinder,Per Dahlqvist,Eva Marie Erfurth,Charlotte Höybye,Karin Larsson,Oskar Ragnarsson,Bertil Ekman,Britt Edén Engström
出处
期刊:European journal of endocrinology [Oxford University Press]
卷期号:186 (3): 329-339 被引量:12
标识
DOI:10.1530/eje-21-0729
摘要

To describe the treatment and long-term outcomes of patients with acromegaly from all healthcare regions in Sweden.Analysis of prospectively reported data from the Swedish Pituitary Register of 698 patients (51% females) with acromegaly diagnosed from 1991 to 2011. The latest clinical follow-up date was December 2012, while mortality data were collected for 28.5 years until June 2019.The annual incidence was 3.7/million; 71% of patients had a macroadenoma, 18% had visual field defects, and 25% had at least one pituitary hormone deficiency. Eighty-two percent had pituitary surgery, 10% radiotherapy, and 39% medical treatment. At the 5- and 10-year follow-ups, insulin-like growth factor 1 levels were within the reference range in 69 and 78% of patients, respectively. In linear regression, the proportion of patients with biochemical control including adjuvant therapy at 10 years follow-up increased over time by 1.23% per year. The standardized mortality ratio (SMR) (95% CI) for all patients was 1.29 (1.11-1.49). For patients with biochemical control at the latest follow-up, SMR was not increased, neither among patients diagnosed between 1991 and 2000, SMR: 1.06 (0.85-1.33) nor between 2001 and2011, SMR: 0.87 (0.61-1.24). In contrast, non-controlled patients at the latest follow-up from both decades had elevated SMR, 1.90 (1.33-2.72) and 1.98 (1.24-3.14), respectively.The proportion of patients with biochemical control increased over time. Patients with biochemically controlled acromegaly have normal life expectancy, while non-controlled patients still have increased mortality. The high rate of macroadenomas and unchanged age at diagnosis illustrates the need for improvements in the management of patients with acromegaly.
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