自主神经系统
脑干
神经科学
下丘脑
脊髓
中枢神经系统
中脑
迷走神经
神经系统
生物
内分泌学
内科学
医学
刺激
心率
血压
作者
Sophia Kristina Rupp,Andreas Stengel
出处
期刊:Peptides
[Elsevier]
日期:2022-03-01
卷期号:149: 170719-170719
被引量:14
标识
DOI:10.1016/j.peptides.2021.170719
摘要
Nesfatin-1, an 82-amino acid polypeptide derived from the precursor protein nucleobindin-2 (NUCB2), was first discovered in 2006 in the rat hypothalamus. The effects and distribution of nesfatin-1 immunopositive neurons in the brain and spinal cord point towards a role of NUCB2/nesfatin-1 in autonomic regulation. Therefore, studies which have been conducted to investigate the interplay between nesfatin-1 and the autonomic nervous system were examined, and the outcomes of this research were summarized. NUCB2/nesfatin-1 immunoreactivity is widely distributed in autonomic centers of the brain and spinal cord in both rodents and humans. In several regions of the hypothalamus, midbrain and brainstem, nesfatin-1 modulates autonomic functions. On the other hand, the autonomic nervous system also influences the activity of nesfatin-1 neurons. Here, the vagus nerve seems to be a crucial factor in the regulation of nesfatin-1. In summary, although data here is still sparse, there is a clear interplay between nesfatin-1 and the autonomic nervous system, the precise clarification of which still requires further research to gain more insight into these complex relationships.
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