骨重建
牙周炎
机制(生物学)
骨免疫学
免疫系统
发病机制
串扰
生物
医学
免疫学
兰克尔
牙科
基因
内科学
遗传学
激活剂(遗传学)
认识论
光学
物理
哲学
作者
Jianwen Deng,Chunting Lu,Qingtong Zhao,Kexiao Chen,Shuyuan Ma,Zejian Li
摘要
Periodontopathic bacteria constantly stimulate the host, which causes an immune response, leading to host-induced periodontal tissue damage. The complex interaction and imbalance between Th17 and Treg cells may be critical in the pathogenesis of periodontitis. Furthermore, the RANKL/RANK/OPG system plays a significant role in periodontitis bone metabolism, and its relationship with the Th17/Treg cell imbalance may be a bridge between periodontal bone metabolism and the immune system. This article reviews the literature related to the Th17/Treg cell imbalance mediated by pathogenic periodontal microbes, and its mechanism involving RANKL/RANK/OPG in periodontitis bone metabolism, in an effort to provide new ideas for the study of the immunopathological mechanism of periodontitis.
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