聚丙烯酰胺
氨基酸
肽合成
肽
试剂
固相合成
相(物质)
高效液相色谱法
生物分子
合成树脂
化学
纤维
有机化学
色谱法
组合化学
材料科学
高分子化学
生物化学
作者
Damilola C. Akintayo,Beatriz G. de la Torre,Yongfu Li,Fernando Alberício
出处
期刊:Polymers
[MDPI AG]
日期:2022-02-25
卷期号:14 (5): 928-928
被引量:4
标识
DOI:10.3390/polym14050928
摘要
Amino-Li-resin is a new and unique polyacrylamide resin presented in the form of fibers and is found to be well suited for solid-phase peptide chemistry. Although amino-Li-resin swells much better in polar solvents, it is also compatible with some non-polar solvents. It comes with a high loading of functional amino groups, thus maximizing its productivity in terms of the amount of peptide per gram of resin. In addition to its mechanical stability, this resin shows excellent stability in basic and acidic reagents; thus, allowing its broad applicability for the synthesis of a wide range of biomolecules. Finally, the appropriateness of amino-Li-resin for solid-phase peptide synthesis (SPPS) has been demonstrated for the synthesis of several model peptides, including difficult sequences and those containing hindered amino acids, all of which afforded excellent crude purity, as shown by high-performance liquid chromatography (HPLC) analysis.
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