检出限
电化学气体传感器
拉曼光谱
碳纳米管
血红素
材料科学
线性范围
选择性
电化学
核化学
化学
纳米技术
色谱法
电极
有机化学
血红素
物理
物理化学
光学
酶
催化作用
作者
Kimia Zarean Mousaabadi,Ali A. Ensafi,Behzad Rezaei
出处
期刊:Chemosphere
[Elsevier]
日期:2022-05-31
卷期号:303: 135149-135149
被引量:20
标识
DOI:10.1016/j.chemosphere.2022.135149
摘要
Due to its toxicological and pharmacological activity, the misuse and overuse of morphine (MO), codeine (CO), and heroine have attracted attention in the medical and forensic toxicology fields. This study proposed a new electrochemical sensor with an acceptable detection limit, linear range, and selectivity for simultaneous determination of MO and CO. This sensor is based on Cu-Hemin metal-organic framework (CHM) and multiwall carbon nanotubes (MWCNTs). First, a facile chemical method was chosen to synthesize CHM and then composite it with MWCNTs. Afterward, the structure of CHM@MWCNTs was verified by XRD, FT-IR, Raman spectroscopy, UV-vis, ICP-OES, FE-SEM, EDX, and elemental mapping. In the next step, under optimal conditions, this electrochemical sensor can sensitive simultaneous determination of MO and CO, showing a dynamic concentration range from 0.09 to 30 μM for both species and a low detection limit of 9.2 nM and 11.2 nM for MO and CO, respectively. Moreover, the applicability in real samples was confirmed by the simultaneous determination of MO and CO in human urine and MO injection. This work reveals a trustable sensor based on MOF and MWCNTs to simultaneously determine opioid drugs in clinical application.
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