鼠李糖乳杆菌
乳酸菌
肠道菌群
益生菌
结肠炎
微生物学
丁酸
肿瘤坏死因子α
炎症性肠病
短链脂肪酸
免疫系统
化学
生物
食品科学
细菌
生物化学
免疫学
丁酸盐
内科学
发酵
医学
疾病
遗传学
作者
Cheng Wan,Wenwen Qian,Wei Liu,Xionge Pi,Meng‐Ting Tang,Xiaolin Wang,Qing Gu,Ping Li,Tao Zhou
摘要
The exopolysaccharides (EPS) produced by Lactobacillus and other probiotics are associated with many benefits, such as immune regulation, antioxidant properties, antitumor effect, and regulation of intestinal microbe homeostasis. In the present study, the modulatory effect of EPS produced by Lactobacillus rhamnosus ZFM231 on the intestinal flora of mice with inflammatory bowel disease induced by dextran sulfate solution was investigated.Results indicated that weight loss, colonic length, the disease activity index score and colonic tissue damage in mice were significantly improved by EPS treatment. Compared with the model group, in the EPS-treated group, the diversity of and the composition of gut microbiota at both phylum and genus levels were found to recover to the levels of normal group, indicating the effective modulation on gut microbiota by EPS; short-chain fatty acids, including acetic acid, propionic acid and butyric acid produced by intestinal microbial metabolism, increased significantly; the level of anti-inflammatory factor transforning growth factor-β significantly increased and the level of pro-inflammatory factor tumor necrosis factor-α significantly decreased in the colonic cells of EPS-treated mice.It is clear that EPS produced by L. rhamnosus ZFM231 could find application in functional foods with the property of anti-ulcerative colitis. The experimental results provide new insights into the probiotic effect of EPS. © 2022 Society of Chemical Industry.
科研通智能强力驱动
Strongly Powered by AbleSci AI