[Changes of serum lipid profiles and the correlation analysis in clinic-pathological features of pancreatic cancer patients].

Objective: To examine the characteristics of blood lipid profile and the correlation with clinic-pathological features of pancreatic cancer patients. Methods: The clinical and pathological data of 265 pancreatic cancer patients who received radical surgical treatment at Department of General Surgery,Qilu Hospital,Shandong University from January 2013 to September 2020 were collected and analyzed retrospectively. Among the 265 pancreatic cancer patients,there were 170 males and 95 females,with age of (61.0±9.6)years(range:28 to 86 years). General information,lipid indicators and clinic-pathological information were collected from electronic medical record system,and follow-up information gained by telephone. According to level of serum lipid in pancreatic cancer patients,265 patients were divided into dyslipidemia group(n=115) and normal lipid group(n=150). Pearson χ2,Student's t tests, variance analysis or univariate Logistic regression was used to analyze the correlation between dyslipidemia and clinico-pathological characteristics of pancreatic cancer,respectively. Kaplan-Meier survival curve was used to assessed the influence of dyslipidemia on prognosis of pancreatic cancer patients. Results: In 265 pancreatic cancer patients,115(43.4%)of them had dyslipidemias,and the most common form was increase of triglyceride(TG)(72.2%). In pancreatic cancer with dyslipidemias group,patients with body mass index ≥25 kg/m2 had higher proportion than normal lipid group(36.1%(26/72) vs. 21.2%(21/99),χ²=4.643,P=0.031); The proportion of carcinoma located at head of pancreas(83.5%(96/115) vs. 40.7%(61/150),χ²=49.412,P<0.01), staging of T1/T2(79.1%(91/115) vs. 60.7%(91/150),χ²=10.316,P<0.01) and lymphatic metastasis(36.5%(42/115) vs. 22.7%(34/150),χ²=6.007,P<0.01) were higher. In patients of pancreatic cancer, dyslipidemias were closely associated with tumor location(OR=10.529,P<0.01)and body mass index(OR=3.671,P=0.008). Serum lipid profile results showed that TG,total cholesterol and high-density lipoprotein(HDL) disorders were associated with tumor location(P<0.05). TG disorder had association with body mass index(P<0.05), and HDL disorder had association with tumor stage(P<0.05). Moreover, the result of survival analysis showed that dyslipidemia was not a factor to impact the prognosis of pancreatic cancer patients underwent surgery(P>0.05). Conclusions: In pancreatic cancer patients,TG disorder was the most common type of dyslipidemia. Dyslipidemia has closely association with clinicopathologic features,including tumor location,body mass index,tumor stage. However,dyslipidemia had little effect on prognosis of pancreatic cancer patients.目的： 探讨胰腺癌患者的血脂谱特点及其与临床和病理学特征的相关性。 方法： 回顾性收集2013年1月至2020年9月在山东大学齐鲁医院普通外科接受根治性手术治疗的265例胰腺癌患者的临床和病理学资料。男性170例，女性95例，年龄（61.0±9.6）岁（范围：28~86岁）。收集患者的一般资料、血脂资料、临床病理学参数及随访信息。根据是否合并血脂异常，将患者分为血脂异常组（n=115）和正常血脂组（n=150）。采用χ²检验、t检验、方差分析或Logistic回归分析血脂异常与胰腺癌临床和病理学特征之间的相关性；采用Kaplan-Meier 曲线分析血脂水平对胰腺癌患者预后的影响。 结果： 265例胰腺癌患者中，115例（43.4%）合并血脂异常，其中以甘油三酯（TG）升高（72.2%）为主。血脂异常组胰腺癌患者中，体重指数≥25 kg/m2的比例高于血脂正常组［36.1%（26/72）比21.2%（21/99）；χ²=4.643，P=0.031］，肿瘤位于胰头的比例更高［83.5%（96/115）比40.7%（61/150）；χ²=49.412，P<0.01］，T1~2期肿瘤的比例更高［79.1%（91/115）比60.7%（91/150）；χ²=10.316，P<0.01］，且淋巴结转移的比例升高［36.5%（42/115）比22.7%（34/150）；χ²=6.007，P=0.013］。胰腺癌患者中，血脂异常与肿瘤部位（OR=10.529，P<0.01）、体重指数（OR=3.671，P=0.008）有相关性；血脂谱分析发现，TG、总胆固醇、高密度脂蛋白（HDL）异常均与肿瘤部位相关（P值均<0.05），其中TG升高还与体重指数相关（P<0.05），而HDL异常与肿瘤分期有相关性（P<0.05）。生存分析结果显示，血脂异常不是影响胰腺癌患者术后总体生存期的预后因素（P>0.05）。 结论： 胰腺癌患者的血脂异常以TG异常为主；血脂异常与胰腺癌患者的肿瘤位置、体重指数、肿瘤分期等临床和病理学特征有相关性；但血脂异常对胰腺癌患者的预后无影响。.