亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Global Prevalence and Clinical Characteristics of Metabolic-associated Fatty Liver Disease: A Meta-Analysis and Systematic Review of 10 739 607 Individuals

脂肪肝 医学 优势比 荟萃分析 内科学 非酒精性脂肪肝 糖尿病 胃肠病学 人口 疾病 诊断优势比 2型糖尿病 内分泌学 环境卫生
作者
Kai En Chan,Tiffany Jia Ling Koh,Ansel Shao Pin Tang,Jingxuan Quek,Jie Ning Yong,Phoebe Wen Lin Tay,Darren Jun Hao Tan,Wen Hui Lim,Snow Yunni Lin,Daniel Q. Huang,Mark Y. Chan,Chin Meng Khoo,Nicholas Chew,Apichat Kaewdech,Naichaya Chamroonkul,Yock Young Dan,Mazen Noureddin,Mark Muthiah,Mohammed Eslam,Cheng Han Ng
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
卷期号:107 (9): 2691-2700 被引量:209
标识
DOI:10.1210/clinem/dgac321
摘要

Abstract Background and Aims Metabolic-associated fatty liver disease (MAFLD) was proposed as a better definition of nonalcoholic fatty liver disease (NAFLD) to encompass the metabolic dysregulation associated with NAFLD. This redefinition challenges our understanding of the disease. Hence, this study sought to conduct an updated analysis of the prevalence, clinical characteristics, and associated factors of MAFLD, with a further sensitivity analysis done based on lean and nonobese MAFLD individuals. Methods Medline and Embase databases were searched to include articles on MAFLD. Meta-analysis of proportions was conducted using the generalized linear mix model. Associating factors were evaluated in conventional pairwise meta-analysis with sensitivity analysis on lean and nonobese MAFLD. Results From pooled analysis involving 3 320 108 individuals, the overall prevalence of MAFLD was 38.77% (95% CI 32.94% to 44.95%); 5.37% (95% CI 4.36% to 6.59%) and 29.78% (95% CI 26.06% to 33.79%) of lean and nonobese individuals, respectively, had MAFLD. Metabolic complications such as hypertension [odds ratio (OR) 2.63, 95% CI 1.85 to 3.74, P < 0.0001 and OR 2.03; 95% CI 1.74 to 2.38, P < 0.0001, respectively] and diabetes (OR 3.80, 95% CI 2.65 to 5.43, P < 0.0001 and OR 3.46, 95% CI 2.81 to 4.27, P < 0.0001, respectively) were found as significant associating factors associated with lean and nonobese MAFLD. Conclusions This meta-analysis supports previous studies in reporting MAFLD to affect more than a third of the global population. While exploration of the pathogenic basis of fatty liver disease without metabolic dysregulation is required, the emphasis on management of concomitant metabolic disease in MAFLD can improve multidisciplinary efforts in managing the complex disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
GLv发布了新的文献求助50
1秒前
2秒前
Tatotota完成签到,获得积分20
4秒前
无心ICE发布了新的文献求助10
7秒前
luckkit完成签到 ,获得积分10
45秒前
浮名半生发布了新的文献求助10
53秒前
54秒前
55秒前
北极星完成签到,获得积分10
1分钟前
木木完成签到 ,获得积分10
1分钟前
1分钟前
power完成签到,获得积分10
1分钟前
shaylie完成签到 ,获得积分10
1分钟前
拼搏的潘子完成签到,获得积分10
1分钟前
脑洞疼应助科研通管家采纳,获得30
1分钟前
搜集达人应助科研通管家采纳,获得10
1分钟前
Ava应助婷子采纳,获得10
1分钟前
1分钟前
负责吃饭完成签到,获得积分10
1分钟前
负责吃饭发布了新的文献求助30
1分钟前
无言完成签到,获得积分10
1分钟前
顾矜应助wind采纳,获得10
1分钟前
1分钟前
sam关闭了sam文献求助
1分钟前
1分钟前
小张完成签到 ,获得积分10
1分钟前
婷子发布了新的文献求助10
1分钟前
蔚欢完成签到 ,获得积分10
1分钟前
Timon完成签到,获得积分10
1分钟前
机智觅柔完成签到 ,获得积分10
1分钟前
孤鸿.完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
2分钟前
wind发布了新的文献求助10
2分钟前
wind完成签到,获得积分10
2分钟前
澄明的晨星完成签到,获得积分10
2分钟前
P_Chem完成签到,获得积分10
2分钟前
光亮代玉完成签到 ,获得积分10
2分钟前
鲤鱼越越完成签到 ,获得积分10
2分钟前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3963149
求助须知:如何正确求助?哪些是违规求助? 3509051
关于积分的说明 11144954
捐赠科研通 3242088
什么是DOI,文献DOI怎么找? 1791744
邀请新用户注册赠送积分活动 873127
科研通“疑难数据库(出版商)”最低求助积分说明 803622