磺胺嘧啶银
神童素
磺胺嘧啶
硝酸银
烧伤
烧伤
医学
总体表面积
微生物学
金黄色葡萄球菌
化学
皮肤病科
伤口愈合
外科
粘质沙雷氏菌
细菌
抗生素
生物
核化学
大肠杆菌
生物化学
基因
遗传学
作者
Nora M. Elkenawy,Heba M. Karam,Dina S. Aboul‐Magd
标识
DOI:10.1016/j.ijbiomac.2022.05.063
摘要
Burn wounds are prone to infections and cause a large amount of death worldwide. Although burn wound is sterile at the beginning but due to the risk factors such as prolonged hospital stay, immune suppression and burn affecting large surface area, it turns to infected burn. This study aims to examine the possible protective properties of silver sulfadiazine embedded in alginate macromolecule to prepare hydrogel. The prepared hydrogel dyed with prodigiosin was used as a smart wound dressing to treat burn wounds that were infected with S. aureus and E. coli. Rats were divided into four groups: (1) control group, (2) burn-infected with S. aureus and E. coli group, (3) burn-infected treated with silver nitrate cream group and (4) burn-infected gamma irradiated silver sulfadiazine-embedded hydrogel dyed with prodigiosin. The biochemical results verified the histopathological results and our findings showed that silver sulfadiazine-embedded hydrogel dyed with prodigiosin is an effective product in compared with silver nitrate cream.
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