表面改性
部分
羧酸盐
纳米技术
材料科学
磁共振成像
纳米颗粒
氟
组合化学
分子
化学
有机化学
物理化学
医学
放射科
作者
Xi Yang,Jinchuang Ning,Yingying Zhao,Suying Xu,Leyu Wang
标识
DOI:10.1002/asia.202200397
摘要
The development of multifunctional nanoplatforms for bioimaging and therapy has attracted extensive attention in recent decades. As an emerging magnetic resonance imaging (MRI) technique, 19 F MRI effectively complements the limit of 1 H MRI owing to trace amount of 19 F atoms existing in the human body, affording high specificity. In this work, a novel molecule (CFO) containing hydrophilic fluorine fragments was synthesized using amino acids as starting materials, which could self-assemble into small nanoprobes via hydrophobic interactions of oleic acid moiety. The as-prepared nanoprobes displayed good relaxation performances thanks to the carboxylate group and sulfoxide group nearby. The nanoprobes successfully demonstrated its capacity for in-vivo 19 F MRI. In addition, CFO could be used as a general fluorine labeling agent for surface functionalization of nanoparticles, which provided a universal method for constructing water-soluble multifunctional nanoplatforms.
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