Peptide deformylase (PDF) is a mononuclear metal ion protein that is responsible for removing the N-formyl group of nascent proteins found in bacteria and chloroplasts in order for them to become mature proteins.From literature it was found that heterocyclic derivatives containing hydroxamic acid and hydroxyl amine exhibit good antibacterial and PDF inhibitory activity.Heterocycles bearing nitrogen, sulphur, oxygen and thiazole moieties constitute the core structure of a number of biologically interesting compounds.Recently 1,3,4 oxadiazole and 1,3,4triazole derivatives received significant attention owing to their diverse range of biological properties particularly being antifungal, antitubercular, antibacterial, antiviral, anticancer and antioxidant.Ethyl-cyano-acetate when treated with sodium hydrate and THF give acetate derivatives, which on further treatment with hydrazine hydrate and various reagent afforded heterocyclic hydroxylamine derivatives.