γ-氨基丁酸受体
帕尔瓦布明
加巴能
胆囊收缩素
神经科学
中间神经元
海马结构
锥体细胞
兴奋剂
巴氯芬
光遗传学
神经传递
化学
生物
受体
抑制性突触后电位
生物化学
作者
Chen Shao,Jiaxue Dong,Mingwei Zhao,Shenhao Liu,Xue Wang,Yang Yu,Lingyan Fang,Ziying Zhu,Qian Chen,Xin Xu,Weining Zhang,Kun Yang
标识
DOI:10.1016/j.neulet.2022.136448
摘要
Combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, we compared GABA release from cholecystokinin-expressing (CCK) and parvalbumin-expressing (PV) interneurons onto CA1 pyramidal neurons. Baclofen, a selective GABAB receptor agonist, inhibited GABAergic synaptic transmission greater from CCK terminals, compared to that from PV terminals. The N-type calcium channels on CCK and P/Q-type calcium channels on PV terminals contributed to the GABAB receptor-mediated inhibition, respectively. Our data thus provide direct evidence that GABAB receptors differentially modulate GABA release from CCK and PV interneurons, adding to an increasing list of differences between these two interneuron subtypes in modulating hippocampal pyramidal neurons.
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