In recent years, there has been increased focus on the calibration of discrete element method (DEM) models to gain improved confidence in the simulation predictions. However, most recent reports have focused on calibration for real particles of idealized shape (e.g., spherical) or large size (e.g., >1 mm), presented complex calibration procedures that may be difficult to adopt in an industrial setting, lack documented experimental validation of the approach, or apply to only a specific material of interest. In this article, we present an industrial perspective on application of DEM models centered on a generalized calibration approach for fine powders with low-to-moderate cohesion that is simple, rapid, and requires minimal experimentation. The approach, based on previous work, is formalized here and utilizes non-rotating spherical parcels to represent a small volume of powder, and in many cases, the simulation results are reasonably predictive of bulk powder flow behavior in dense systems. The assumptions and limitations of the approach, along with some guidelines for application are discussed. Finally, several examples from the literature demonstrating success of the approach in industrially-relevant powder processes with comparison to either commonly accepted theory or experimental data are presented.