化学
亲核细胞
钯
艾伦
催化作用
芳基
盐(化学)
离子键合
有机化学
组合化学
药物化学
离子
烷基
作者
Yajun Li,Jingjing Bao,Rongbiao Wei,Hongli Bao
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2022-03-17
卷期号:54 (16): 3631-3641
被引量:2
摘要
Abstract Ionic 1,4-difunctionalization of 1,3-enynes has often been conducted with strong nucleophiles or 1,3-enynes that are activated by an electron-withdrawing group. In this work, a palladium-catalyzed three-component ionic 1,4-carboarylation of 1,3-enynes is reported with arylated 1,3-enynes as the substrates. This method can afford various tetrasubstituted allenes with different functionalities. The palladium salt might play a key dual role in the reaction: as the catalyst to catalyze the cross-coupling reaction and as a Lewis acid to facilitate the nucleophilic attack. The synthetic value of this method is demonstrated by the further cyclization, decoration, and hydrolysis of the allene products.
科研通智能强力驱动
Strongly Powered by AbleSci AI