生物
重编程
神经科学
祖细胞
神经干细胞
祖细胞
细胞生物学
干细胞
细胞
遗传学
作者
Yunjia Zhang,Boxun Li,Sergio Giuseppe Cananzi,Chuanhui Han,Leilei Wang,Yuhua Zou,Yang–Xin Fu,Gary C. Hon,Chunli Zhang
标识
DOI:10.1073/pnas.2107339119
摘要
SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
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