小胶质细胞
神经退行性变
离体
淀粉样蛋白(真菌学)
医学
β淀粉样蛋白
体内
阿尔茨海默病
神经科学
病理
免疫学
生物
疾病
炎症
生物技术
作者
Sunjun Lee,Wonseok Choi
出处
期刊:Chonnam medical journal
[Chonnam National University Medical School]
日期:2022-01-01
卷期号:58 (1): 13-13
标识
DOI:10.4068/cmj.2022.58.1.13
摘要
Alzheimer's disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established. We thus investigated the role of microglia in AD models using a primary culture and an ex-vivo assay. We showed that oligomerized Aβ is toxic to neurons in the primary culture. In the ex-vivo assay, a microglial cell line removed amyloid plaques in the brain of 5XFAD (AD model) mice. To verify if microglia can be protective for the neuron, we co-cultured neurons with primary microglia and treated them with Aβ. The loss of neurons, induced by amyloid toxicity, was attenuated by co-cultured microglia. Taken together, our data suggest that microglia promote neuronal survival by phagocytic clearance of Aβ in AD models.
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