Antimicrobial Properties of Graphene Oxide Nanosheets: Why Size Matters

抗菌剂 石墨烯 超声 纳米技术 材料科学 氧化物 涂层 化学 纳米材料 化学工程 有机化学 色谱法 工程类
作者
François Perreault,Andréia Fonseca de Faria,Siamak Nejati,Menachem Elimelech
出处
期刊:ACS Nano [American Chemical Society]
卷期号:9 (7): 7226-7236 被引量:845
标识
DOI:10.1021/acsnano.5b02067
摘要

Graphene oxide (GO) is a promising material for the development of antimicrobial surfaces due to its contact-based antimicrobial activity. However, the relationship between GO physicochemical properties and its antimicrobial activity has yet to be elucidated. In this study, we investigated the size-dependency of GO antimicrobial activity using the Gram-negative bacteria Escherichia coli. GO suspensions of average sheet area ranging from 0.01 to 0.65 μm2 were produced and their antimicrobial activity evaluated in cell suspensions or as a model GO surface coating. The antimicrobial activity of GO surface coatings increased 4-fold when GO sheet area decreased from 0.65 to 0.01 μm2. The higher antimicrobial effect of smaller GO sheets is attributed to oxidative mechanisms associated with the higher defect density of smaller sheets. In contrast, in suspension assays, GO interacted with bacteria in a cell entrapment mechanism; in this case, the antimicrobial effect of GO increased with increasing sheet area, with apparent complete inactivation observed for the 0.65 μm2 sheets after a 3 h exposure. However, cell inactivation by GO entrapment was reversible and all initially viable cells could be recovered when separated from GO sheets by sonication. These findings provide useful guidelines for future development of graphene-based antimicrobial surface coatings, where smaller sheet sizes can increase the antimicrobial activity of the material. Our study further emphasizes the importance of an accurate assessment of the antimicrobial effect of nanomaterials when used for antimicrobial surface design.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
酷炫迎波完成签到,获得积分10
1秒前
2秒前
EZIII完成签到,获得积分10
3秒前
5秒前
西门灵薇完成签到,获得积分10
5秒前
kelly完成签到,获得积分10
7秒前
麦可发布了新的文献求助10
7秒前
CY发布了新的文献求助10
8秒前
9秒前
IvanMikola发布了新的文献求助20
10秒前
10秒前
Zzy发布了新的文献求助10
11秒前
12秒前
12秒前
木子相心完成签到,获得积分10
12秒前
13秒前
小洋甘完成签到,获得积分10
13秒前
酷波er应助iii采纳,获得10
13秒前
15秒前
玛卡巴卡完成签到,获得积分10
15秒前
Happy422发布了新的文献求助30
15秒前
16秒前
敬老院N号发布了新的文献求助10
16秒前
16秒前
daijin发布了新的文献求助10
17秒前
17秒前
Rashalin发布了新的文献求助10
17秒前
敬老院N号发布了新的文献求助10
18秒前
敬老院N号发布了新的文献求助10
18秒前
敬老院N号发布了新的文献求助10
18秒前
敬老院N号发布了新的文献求助10
18秒前
敬老院N号发布了新的文献求助10
18秒前
FashionBoy应助vitamin采纳,获得10
18秒前
18秒前
思源应助小李博士采纳,获得10
18秒前
Yuan完成签到,获得积分10
18秒前
爱笑花卷完成签到 ,获得积分10
20秒前
格洛喜静发布了新的文献求助10
21秒前
21秒前
21秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 600
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3064589
求助须知:如何正确求助?哪些是违规求助? 2719285
关于积分的说明 7463273
捐赠科研通 2365693
什么是DOI,文献DOI怎么找? 1254139
科研通“疑难数据库(出版商)”最低求助积分说明 608796
版权声明 596684