取代基
化学
芳基
配体(生物化学)
多元化(营销策略)
弗里德尔-克拉夫茨反应
催化作用
立体化学
有机化学
业务
生物化学
营销
受体
烷基
作者
Uttam Dutta,Soumen K. Maiti,Trisha Bhattacharya,Debabrata Maiti
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-05-14
卷期号:372 (6543)
被引量:249
标识
DOI:10.1126/science.abd5992
摘要
Targeting distal C–H bonds in arenes The Friedel-Crafts reaction is among the oldest in organic chemistry. For well over a century, chemists have relied on electronic effects intrinsic to aryl rings to append substituents at specific sites along the periphery. However, only in the past decade have they devised catalytic techniques that over-ride these preferences so that new groups usually drawn to the neighboring sites of an existing substituent instead wind up two or three carbons away. Dutta et al. review progress in this field, highlighting elaborate directing groups and mediators as well as sophisticated ligand design. Science , this issue p. eabd5992
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