Visualization of Fibroblast Activation After Myocardial Infarction Using 68Ga-FAPI PET

医学 心肌梗塞 心脏病学 冠状动脉疾病 内科学 核医学 成纤维细胞活化蛋白 梗塞 癌症
作者
Lukas Kessler,Jana Kupusović,Justin Ferdinandus,Nader Hirmas,Lale Umutlu,Fadi Zarrad,Michael Nader,Wolfgang P. Fendler,Matthias Totzeck,Reza Wakili,Thomas Schlosser,Tienush Rassaf,Christoph Rischpler,Johannes Siebermair
出处
期刊:Clinical Nuclear Medicine [Lippincott Williams & Wilkins]
卷期号:46 (10): 807-813 被引量:57
标识
DOI:10.1097/rlu.0000000000003745
摘要

The aim of this retrospective analysis was to examine the pattern of cardiac 68Ga-fibroblast-activation protein-α inhibitor (FAPI) uptake in patients after acute myocardial infarction (AMI) using PET and to investigate its association with results of coronary angiography. We correlated FAPI uptake with biomarkers of myocardial damage including left ventricular function.A cohort of 10 patients with no history of coronary artery disease underwent PET 18 ± 20.6 days after AMI (ST-segment elevation myocardial infarction [n = 5] and non-ST-segment elevation infarction [n = 5]), respectively. SUVmax, SUVmean, and SUVpeak of localized tracer uptake were calculated; tracer uptake volume was reported as fibroblast activation volume (FAV), with imaging data being correlated with clinical parameters. Focal FAPI uptake was observed in all patients. Average uptake at 10 minutes postinjection was 8.9 ± 4.4 (SUVmax), 7.6 ± 4.0 (SUVpeak), and 5.3 ± 2.8 (SUVmean), respectively. Affected myocardium showed a partial to complete match between tracer uptake and confirmed culprit lesion by coronary angiography in 44.4% and 55.6% of patients, respectively. A strong correlation between FAV and peak creatine kinase level (r = 0.90, P < 0.01) and inverse correlation of FAV with left ventricular function (r = -0.69, P < 0.05) was observed.This analysis demonstrates in vivo visualization of fibroblast activation after AMI. The uptake area showed a very good agreement with the affected coronary territory. A strong correlation of the de novo established parameter FAV with left ventricular function and peak creatine kinase was observed. This imaging modality may provide important insights into mechanisms of structural remodeling after AMI at an early stage.
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