Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis

医学 荟萃分析 诊断优势比 肝细胞癌 子群分析 超声造影 置信区间 优势比 内科学 科克伦图书馆 肝硬化 肝内胆管癌 诊断试验中的似然比 超声波 出版偏见 胃肠病学 曲线下面积 接收机工作特性 放射科
作者
Yanling Chen,Yu-li Zhu,Kailing Chen,Hantao Wang,Weibin Zhang,Jingwen Bao,Wen-Ping Wang
出处
期刊:Clinical Hemorheology and Microcirculation [IOS Press]
卷期号:: 1-17 被引量:3
标识
DOI:10.3233/ch-211145
摘要

AIM: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). The methodologic quality was assessed by the QUADAS-2 tool. Subgroup analyses, meta-regression and investigation of publication bias were performed to identify the source of heterogeneity. RESULTS: A total of eight studies were included, consisting of 1,116 patients with HCC and 529 with ICC. The general diagnostic performance of CEUS in distinguishing ICC and HCC were as follows: pooled sensitivity, 0.92 (95% CI: 0.84–0.96); pooled specificity, 0.87 (95% CI: 0.79–0.92); pooled PLR, 7.1 (95% CI: 4.1–12.0); pooled NLR, 0.09 (95% CI: 0.05–0.19); pooled DOR, 76 (95% CI: 26–220) and AUC, 0.95(95% CI: 0.93–0.97). Different liver background may be a potential factor that influenced the diagnostic accuracy of CEUS according to the subgroup analysis, with the pooled DOR of 89.67 in the mixed liver background group and 46.87 in the cirrhosis group, respectively. Six informative CEUS features that may help differentiate HCC from ICC were extracted. The three CEUS features favoring HCC were arterial phase hyperenhancement(APHE), mild washout and late washout (>60s); the three CEUS favoring ICC were arterial rim enhancement, marked washout and early washout(<60s). No potential publication bias was observed. CONCLUSION: CEUS showed great diagnostic ability in differentiating ICC from HCC, which may be promising for noninvasive evaluation of these diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
leeom发布了新的文献求助10
3秒前
Timo干物类完成签到,获得积分10
3秒前
北冥有鱼给北冥有鱼的求助进行了留言
3秒前
3秒前
王冉冉发布了新的文献求助30
3秒前
Ava应助易拉罐采纳,获得10
4秒前
隐形曼青应助无心的土豆采纳,获得10
4秒前
乐于助人大好人完成签到 ,获得积分10
4秒前
ZZQ完成签到,获得积分10
8秒前
量子星尘发布了新的文献求助10
8秒前
Lina HE完成签到 ,获得积分10
8秒前
852应助科研通管家采纳,获得10
8秒前
Ava应助科研通管家采纳,获得10
9秒前
ED应助科研通管家采纳,获得10
9秒前
领导范儿应助科研通管家采纳,获得10
9秒前
9秒前
Akim应助科研通管家采纳,获得10
9秒前
进步完成签到,获得积分10
9秒前
852应助科研通管家采纳,获得10
9秒前
ED应助科研通管家采纳,获得10
9秒前
英俊的铭应助科研通管家采纳,获得10
9秒前
SciGPT应助科研通管家采纳,获得10
9秒前
Akim应助科研通管家采纳,获得10
9秒前
iNk应助dh采纳,获得20
9秒前
orixero应助科研通管家采纳,获得30
9秒前
思源应助科研通管家采纳,获得10
9秒前
wanci应助科研通管家采纳,获得10
9秒前
赘婿应助科研通管家采纳,获得10
10秒前
wanci应助科研通管家采纳,获得10
10秒前
李健应助科研通管家采纳,获得10
10秒前
10秒前
10秒前
wanci应助科研通管家采纳,获得10
10秒前
10秒前
10秒前
10秒前
10秒前
科研通AI2S应助科研通管家采纳,获得10
10秒前
10秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048