清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis

医学 荟萃分析 诊断优势比 肝细胞癌 子群分析 超声造影 置信区间 优势比 内科学 科克伦图书馆 肝硬化 肝内胆管癌 诊断试验中的似然比 超声波 出版偏见 胃肠病学 曲线下面积 接收机工作特性 放射科
作者
Yanling Chen,Yu-li Zhu,Kailing Chen,Hantao Wang,Weibin Zhang,Jingwen Bao,Wen-Ping Wang
出处
期刊:Clinical Hemorheology and Microcirculation [IOS Press]
卷期号:: 1-17 被引量:3
标识
DOI:10.3233/ch-211145
摘要

AIM: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). The methodologic quality was assessed by the QUADAS-2 tool. Subgroup analyses, meta-regression and investigation of publication bias were performed to identify the source of heterogeneity. RESULTS: A total of eight studies were included, consisting of 1,116 patients with HCC and 529 with ICC. The general diagnostic performance of CEUS in distinguishing ICC and HCC were as follows: pooled sensitivity, 0.92 (95% CI: 0.84–0.96); pooled specificity, 0.87 (95% CI: 0.79–0.92); pooled PLR, 7.1 (95% CI: 4.1–12.0); pooled NLR, 0.09 (95% CI: 0.05–0.19); pooled DOR, 76 (95% CI: 26–220) and AUC, 0.95(95% CI: 0.93–0.97). Different liver background may be a potential factor that influenced the diagnostic accuracy of CEUS according to the subgroup analysis, with the pooled DOR of 89.67 in the mixed liver background group and 46.87 in the cirrhosis group, respectively. Six informative CEUS features that may help differentiate HCC from ICC were extracted. The three CEUS features favoring HCC were arterial phase hyperenhancement(APHE), mild washout and late washout (>60s); the three CEUS favoring ICC were arterial rim enhancement, marked washout and early washout(<60s). No potential publication bias was observed. CONCLUSION: CEUS showed great diagnostic ability in differentiating ICC from HCC, which may be promising for noninvasive evaluation of these diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
未来1发布了新的文献求助10
7秒前
25秒前
慕青应助科研通管家采纳,获得10
30秒前
充电宝应助科研通管家采纳,获得10
31秒前
李爱国应助科研通管家采纳,获得10
31秒前
34秒前
39秒前
丘比特应助未来2采纳,获得10
44秒前
55秒前
飘逸的幻柏关注了科研通微信公众号
58秒前
牛八先生完成签到,获得积分10
1分钟前
1分钟前
最棒哒完成签到 ,获得积分10
1分钟前
2分钟前
2分钟前
噜噜发布了新的文献求助10
2分钟前
深情安青应助科研通管家采纳,获得10
2分钟前
酷波er应助科研通管家采纳,获得10
2分钟前
3分钟前
Maps发布了新的文献求助10
3分钟前
酷波er应助Maps采纳,获得10
3分钟前
Maps完成签到,获得积分20
4分钟前
月儿完成签到 ,获得积分10
4分钟前
jyy发布了新的文献求助20
4分钟前
胡可完成签到 ,获得积分10
4分钟前
蚂蚁踢大象完成签到 ,获得积分10
5分钟前
5分钟前
噜噜发布了新的文献求助10
5分钟前
5分钟前
科研佟完成签到 ,获得积分10
5分钟前
Bin_Liu发布了新的文献求助10
6分钟前
NexusExplorer应助科研通管家采纳,获得10
6分钟前
噜噜完成签到 ,获得积分20
6分钟前
nojego完成签到,获得积分10
7分钟前
7分钟前
带路发布了新的文献求助10
7分钟前
柯伊达完成签到 ,获得积分10
7分钟前
朴素的山蝶完成签到 ,获得积分10
8分钟前
氯丙嗪完成签到 ,获得积分0
9分钟前
evanevanus完成签到,获得积分10
9分钟前
高分求助中
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3963228
求助须知:如何正确求助?哪些是违规求助? 3509100
关于积分的说明 11145240
捐赠科研通 3242230
什么是DOI,文献DOI怎么找? 1791811
邀请新用户注册赠送积分活动 873168
科研通“疑难数据库(出版商)”最低求助积分说明 803643