Two‐layered Au@Ag Bimetallic Nanocomposites‐poly (L‐Met) Platform for Highly Sensitive Chlorpheniramine Maleate Detection

Abstract The two‐layered bimetallic Au@Ag and poly(L‐methionine) (Au@Ag/p‐L‐met) sensor was newly developed for the electrochemical determination of chlorpheniramine maleate (CPM). After electropolymerization of L‐met, bimetallic surfaces were prepared by electrodeposition of Au@Ag nanoparticles on the p‐L‐met/PGE. The surface characterization was carried out by scanning electron microscopy (SEM), Energy Dispersive X‐ray spectroscopy (EDX), Cyclic Voltammetry (CV) and Electrochemical impedance spectroscopy (EIS). The sensor shows good electrocatalytic activity, high sensitivity, wide linear range (0.87–600.0 μM) and a low detection limit (0.26 μM) by using Differential pulse voltammetry (DPV). The sensor was used to determine CPM in pharmaceutical samples with satisfactory results.