光热治疗
伤口愈合
材料科学
生物医学工程
光热效应
多孔性
纳米技术
氧化物
一氧化氮
再生(生物学)
石墨烯
化学
复合材料
外科
医学
冶金
有机化学
细胞生物学
生物
作者
Shun Yao,Yuetong Wang,Junjie Chi,Yunru Yu,Yuanjin Zhao,Yuan Luo,Sheng Wang
标识
DOI:10.1002/advs.202103449
摘要
Patches with the capacity of controllable delivering active molecules toward the wound bed to promote wound healing are expectant all along. Herein, a novel porous metal-organic framework (MOF) microneedle (MN) patch enabling photothermal-responsive nitric oxide (NO) delivery for promoting diabetic wound healing is presented. As the NO-loadable copper-benzene-1,3,5-tricarboxylate (HKUST-1) MOF is encapsulated with graphene oxide (GO), the resultant NO@HKUST-1@GO microparticles (NHGs) are imparted with the feature of near-infrared ray (NIR) photothermal response, which facilitate the controlled release of NO molecules. When these NHGs are embedded in a porous PEGDA-MN, the porous structure, larger specific surface area, and sufficient mechanical strength of the integrated MN could promote a more accurate and deeper delivery of NO molecules into the wound site. By applying the resultant NHG-MN to the wound of a type I diabetic rat model, the authors demonstrate that it is capable of accelerating vascularization, tissue regeneration, and collagen deposition, indicating its bright prospect applied in wound healing and other therapeutic scenarios.
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