内生真菌在植物防御中的应用
圆二色性
细胞毒性
真菌
立体化学
孢菌
化学
抗菌活性
内生菌
植物
绝对构型
体外
生物
细菌
生物化学
遗传学
作者
Gaoran Liu,Ruiyun Huo,Yanan Zhai,Ling Liu
标识
DOI:10.3389/fmicb.2021.641504
摘要
Three new secondary metabolites pestalothenins A–C ( 1 – 3 ), including two new humulane-derived sesquiterpeniods ( 1 and 2 ) and one new caryophyllene-derived sesquiterpeniod ( 3 ), together with five known compounds ( 4 – 8 ) were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae (N635). Their structures were elucidated by the extensive analyses of HRESIMS and NMR spectroscopic data. The absolute configurations of 1 – 3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. The cytotoxic effects of these compounds were evaluated in vitro . Compound 6 showed moderate cytotoxicity against T24 and MCF7 cell lines. In addition, compounds 1 – 8 were also evaluated for antibacterial activity.
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