间充质干细胞
活性氧
化学
生物相容性
氧化铈
细胞生物学
微泡
纳米技术
抗氧化剂
炎症
生物物理学
材料科学
生物化学
免疫学
生物
医学
小RNA
催化作用
有机化学
基因
作者
Jiawei Zhao,Yugang Wang,Wenjing Wang,Ying Tian,Zhongdong Gan,Yanlei Wang,Hongyan He,Wei Chen,Xiao Zhang,Yuanbin Wu,Rongrong Jia,Min Shi,Wei Wei,Guanghui Ma
出处
期刊:Nano Today
[Elsevier]
日期:2021-08-31
卷期号:40: 101282-101282
被引量:26
标识
DOI:10.1016/j.nantod.2021.101282
摘要
Reactive oxygen species (ROS) are key contributors to inflammatory progression and damage. Upon clinical and experimental observation of vascular abnormalities in acute inflammatory diseases, we explore cellular vesicles as templates and carriers to elevate therapeutic performance of nano-antioxidant. Specifically, we develop a mild one-pot approach for in situ growth of cerium oxide (Ce) nanocrystals onto nano-sized red blood cells vesicles (ReVs). Besides excellent biocompatibility, Ce-ReVs have very high ROS-scavenging activity, which is experimentally and theoretically explained by discovering the unique functions of membrane lipids in optimizing Ce nanocrystals with ultrasmall size (~ 3 nm) and ultrahigh Ce(III) content (~ 60.8%). In colitis and acute liver injury models, Ce-ReVs notably enhance accumulation at the inflamed sites and confer strong ROS elimination. Moreover, we upgrade the system by hybridizing ReVs with mesenchymal stem cell-derived exosomes and demonstrate additional repair function of highly damaged tissues, further verifying the satisfactory flexibility and therapeutic efficacy.
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