Visible-Light-Mediated Modification and Manipulation of Biomacromolecules

生物正交化学 化学 背景(考古学) 纳米技术 核酸 翻译后修饰 组合化学 生物化学 点击化学 生物 古生物学 材料科学
作者
Vivian M. Lechner,Manuel Nappi,Patrick J. Deneny,Sarah Folliet,John C. K. Chu,Matthew J. Gaunt
出处
期刊:Chemical Reviews [American Chemical Society]
卷期号:122 (2): 1752-1829 被引量:119
标识
DOI:10.1021/acs.chemrev.1c00357
摘要

Chemically modified biomacromolecules─i.e., proteins, nucleic acids, glycans, and lipids─have become crucial tools in chemical biology. They are extensively used not only to elucidate cellular processes but also in industrial applications, particularly in the context of biopharmaceuticals. In order to enable maximum scope for optimization, it is pivotal to have a diverse array of biomacromolecule modification methods at one's disposal. Chemistry has driven many significant advances in this area, and especially recently, numerous novel visible-light-induced photochemical approaches have emerged. In these reactions, light serves as an external source of energy, enabling access to highly reactive intermediates under exceedingly mild conditions and with exquisite spatiotemporal control. While UV-induced transformations on biomacromolecules date back decades, visible light has the unmistakable advantage of being considerably more biocompatible, and a spectrum of visible-light-driven methods is now available, chiefly for proteins and nucleic acids. This review will discuss modifications of native functional groups (FGs), including functionalization, labeling, and cross-linking techniques as well as the utility of oxidative degradation mediated by photochemically generated reactive oxygen species. Furthermore, transformations at non-native, bioorthogonal FGs on biomacromolecules will be addressed, including photoclick chemistry and DNA-encoded library synthesis as well as methods that allow manipulation of the activity of a biomacromolecule.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SciGPT应助zj采纳,获得10
1秒前
Ava应助阿湫采纳,获得10
1秒前
meng123完成签到,获得积分20
2秒前
x5kyi完成签到,获得积分10
3秒前
爆米花应助肖遥采纳,获得10
4秒前
Xx完成签到,获得积分10
4秒前
4秒前
7秒前
烟里戏完成签到 ,获得积分10
9秒前
shuangfeng1853完成签到 ,获得积分10
9秒前
林子青发布了新的文献求助10
9秒前
10秒前
aa完成签到,获得积分10
10秒前
CXC完成签到,获得积分10
10秒前
12秒前
Zzz发布了新的文献求助10
12秒前
上官若男应助袁凯文采纳,获得10
13秒前
13秒前
褚晣完成签到,获得积分10
13秒前
ATTENTION完成签到,获得积分10
14秒前
14秒前
周欣玙完成签到,获得积分10
14秒前
14秒前
学不懂数学应助as采纳,获得30
14秒前
传奇3应助YiWei采纳,获得10
15秒前
阿湫发布了新的文献求助10
15秒前
why完成签到,获得积分10
15秒前
15秒前
慕青应助Zard采纳,获得10
18秒前
肖遥发布了新的文献求助10
19秒前
19秒前
天气一级棒完成签到,获得积分10
20秒前
TAA66完成签到,获得积分10
20秒前
小凯同学完成签到,获得积分10
20秒前
20秒前
星辰完成签到,获得积分10
23秒前
gomm完成签到,获得积分10
23秒前
星辰大海应助票子采纳,获得10
24秒前
Accpted河豚完成签到,获得积分10
24秒前
苏唱发布了新的文献求助10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048