毒力
信号转导
微生物学
平衡
突变体
病菌
致病岛
先天免疫系统
细胞信号
分泌物
细菌外膜
基因
肠沙门氏菌
生物发生
功能(生物学)
作者
Eduardo A. Groisman,Alexandre Duprey,Jeongjoon Choi
标识
DOI:10.1128/mmbr.00176-20
摘要
The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis, and resistance to a variety of antimicrobial agents, including acidic pH and cationic antimicrobial peptides, in several Gram-negative bacterial species. Best understood in Salmonella enterica serovar Typhimurium, the PhoP/PhoQ system consists o-regulated gene products alter PhoP-P amounts, even under constant inducing conditions. PhoP-P controls the abundance of hundreds of proteins both directly, by having transcriptional effects on the corresponding genes, and indirectly, by modifying the abundance, activity, or stability of other transcription factors, regulatory RNAs, protease regulators, and metabolites. The investigation of PhoP/PhoQ has uncovered novel forms of signal transduction and the physiological consequences of regulon evolution.
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