光敏剂
铼
上睑下垂
光动力疗法
免疫原性
化学
癌症研究
免疫系统
程序性细胞死亡
细胞凋亡
生物化学
医学
免疫学
有机化学
无机化学
作者
Xuxian Su,Wenjin Wang,Qian Cao,Hang Zhang,Bin Liu,Yu‐Yi Ling,Xiaotong Zhou,Zong‐Wan Mao
标识
DOI:10.1002/anie.202115800
摘要
Abstract An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti‐tumor immune effect. We designed a carbonic anhydrase IX (CAIX)‐anchored rhenium(I) photosensitizer, named CA‐Re , that not only performs type‐I and type‐II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar‐level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity. CA‐Re could disrupt and self‐report the loss of membrane integrity simultaneously. This promoted the maturation and antigen‐presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge, CA‐Re is the first metal complex‐based pyroptosis inducer.
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