Studies on the compatibility mechanism and material basis of Danggui Buxue Decoction against anemia mice using metabonomics and network pharmacology.

化学 中医药 传统医学 药代动力学 毒性 口服
作者
YueTao Liu,Yanhong Ju,Xue-Mei Qin
出处
期刊:Journal of Pharmacy and Pharmacology [Oxford University Press]
卷期号:73 (6): 767-777 被引量:1
标识
DOI:10.1093/jpp/rgab016
摘要

Objectives To reveal the compatibility mechanism and material basis of Danggui Buxue decoction (DBD) against anaemia. Methods UHPLC-Q-Exactive-MS based serum metabonomics was applied to decipher the compatibility of DBD against anaemia mice. Meanwhile, network pharmacology was used to reveal the material basis of DBD based on the obtained differential metabolites. Key findings Metabonomic results indicated that 17 serum differential metabolites were closely related to anaemia. DBD, Huangqi (HQ) and Danggui (DG) could significantly ameliorate 13, 6 and 4 serum metabolites in anaemia mice, respectively. 17 serum differential metabolites were linked 140 corresponding targeted genes obtained by Metscape. In addition, 6649 targets genes related anaemia were obtained by network pharmacology. At last, six important targets genes were screened as hopeful targets for the treatment of anaemia through integrating them. Molecular docking further illustrated that eight active components of DBD including mairin, hederagenin, etc. played important roles in treating anaemia. Conclusions DBD produced the best effect by compatibility with HQ and DG in treating anaemia. The approach provided the insights into the compatibility mechanism and material basis of TCM in treating anaemia coupling network pharmacology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
深情安青应助一二不休采纳,获得10
刚刚
2秒前
123完成签到,获得积分10
2秒前
不扯先生完成签到,获得积分10
3秒前
柳絮完成签到,获得积分20
4秒前
lll完成签到,获得积分10
4秒前
sdl完成签到,获得积分10
4秒前
Orange应助孟婆的碗采纳,获得10
5秒前
zhangmy1989发布了新的文献求助30
5秒前
5秒前
清秀的不言完成签到 ,获得积分10
5秒前
杂化轨道退役研究员完成签到,获得积分10
5秒前
FashionBoy应助tanglu采纳,获得10
6秒前
7秒前
闪闪如南完成签到,获得积分10
8秒前
wjxcl完成签到,获得积分10
9秒前
9秒前
9秒前
12233完成签到,获得积分10
10秒前
10秒前
洪武完成签到,获得积分20
10秒前
11秒前
Yuantian发布了新的文献求助10
12秒前
传奇3应助浪花淘尽英雄采纳,获得10
13秒前
流川枫完成签到,获得积分10
13秒前
赘婿应助leo采纳,获得10
13秒前
追寻夏烟完成签到 ,获得积分10
14秒前
闪闪寒云完成签到 ,获得积分10
14秒前
13633501455完成签到 ,获得积分10
15秒前
阿里完成签到,获得积分10
15秒前
蓁蓁发布了新的文献求助10
16秒前
科研通AI5应助加百莉采纳,获得10
16秒前
WELXCNK完成签到,获得积分10
17秒前
GG波波完成签到,获得积分10
18秒前
susu完成签到 ,获得积分10
18秒前
19秒前
19秒前
海阔天空发布了新的文献求助10
20秒前
Loooong发布了新的文献求助10
21秒前
云影箫羽完成签到 ,获得积分10
22秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048