胰岛素
胰岛素受体
胰岛素抵抗
糖尿病
2型糖尿病
受体
信号转导
胰岛素类似物
内分泌学
医学
人胰岛素
生物
内科学
生物信息学
细胞生物学
作者
Morris F. White,C. Ronald Kahn
标识
DOI:10.1016/j.molmet.2021.101304
摘要
The discovery of insulin 100 years ago and its application to the treatment of human disease in the years since have marked a major turning point in the history of medicine. The availability of purified insulin allowed for the establishment of its physiological role in the regulation of blood glucose and ketones, the determination of its amino acid sequence, and the solving of its structure. Over the last 50 years, the function of insulin has been applied into the discovery of the insulin receptor and its signaling cascade to reveal the role of impaired insulin signaling—or resistance—in the progression of type 2 diabetes. It has also become clear that insulin signaling can impact not only classical insulin-sensitive tissues, but all tissues of the body, and that in many of these tissues the insulin signaling cascade regulates unexpected physiological functions. Despite these remarkable advances, much remains to be learned about both insulin signaling and how to use this molecular knowledge to advance the treatment of type 2 diabetes and other insulin-resistant states.
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