活性氧
生物相容性
光动力疗法
自愈水凝胶
材料科学
伤口愈合
医学
生物医学工程
纳米技术
化学
外科
高分子化学
生物化学
有机化学
冶金
作者
Kun Zhou,Dongdong Chigan,Letian Xu,Chenjing Liu,Rui Ding,Guoping Li,Zixi Zhang,Dandan Pei,Ang Li,Baolin Guo,Xuzhou Yan,Gang He
出处
期刊:Small
[Wiley]
日期:2021-07-11
卷期号:17 (33)
被引量:22
标识
DOI:10.1002/smll.202101858
摘要
Photo-electronic devices based on reactive oxygen species (ROS) generation suffer a crucial limitation in wound treatment due to their sandwich structure, which prevents the contact of ROS with wound tissue. In this work, the first anti-sandwich structured visible-light/electricity dual-responsive wound dressing is constructed for treatment of methicillin-resistant Staphylococcus aureus (MRSA), based on selenoviologen-appendant polythiophene (SeV2+ -PT)-containing polyacrylamide hydrogels. The new wound dressing is named an anti-sandwich structured photo-electronic wound dressing (PEWD). The unique structure of PEWD enables its use in synergistic electrodynamic and photodynamic therapy (EDT and PDT), providing rapid, on-demand, and sustained generation of ROS in situ via short-time light irradiation and/or wireless-controlled electrification. The PEWD possesses good flexibility, excellent biocompatibility, and fast response, as well as sustained ROS generation in a physiological environment. Animal experiments demonstrate effective ROS generation in 6 s under irradiation and electrification, inhibiting infection at an early stage, and substantially shortening the healing time of bacterial infection (to within 7 days). This proof-of-concept research holds great promise in developing new flexible PEWD, and novel strategies to improve wound treatment.
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