光热治疗
免疫系统
材料科学
癌症研究
透明质酸酶
细胞外基质
佐剂
间质细胞
免疫增强剂
透明质酸
黑色素瘤
癌细胞
纳米技术
细胞生物学
医学
免疫学
癌症
生物
内科学
生物化学
酶
解剖
作者
Ting He,Yu Luo,Qin Zhang,Zening Men,Tong Su,Linpeng Fan,Hangrong Chen,Teng Shen
标识
DOI:10.1021/acsami.1c06725
摘要
For melanoma with high lethality and metastasis rate, traditional therapy has limited effects; local photothermal therapy (PTT) synergetic with immune therapy for cancer treatment can perhaps improve the situation. However, because of the natural existence of the tumor matrix barrier, the penetration depth of drugs and immune cells often dampens the efficacy of cancer treatment. Herein, we report an innovative synergetic PTT and immune therapy through dissolving microneedles for the codelivery of the hyaluronidase-modified semiconductor polymer nanoparticles containing poly(cyclopentadithiophene-alt-benzothiadiazole) and immune adjuvant polyinosinic–polycytidylic acid (PIC). Benefiting from the dissolution of an extracellular matrix of hyaluronidase, the semiconductor polymer nanoparticles and PIC penetrate the tumor deeply, under synergetic therapy with PTT, activating the immune cells and enhancing the T-cell immune response for inhibition of tumor growth and metastasis. This study provides a promising platform for effective melanoma treatment and a novel strategy to overcome the stromal barrier.
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