高价分子
化学
电催化剂
电化学
碘
芳基
电子转移
组合化学
光化学
无机化学
有机化学
电极
物理化学
烷基
作者
Asim Maity,Brandon L. Frey,Nathanael D. Hoskinson,David C. Powers
摘要
Development of new electrosynthetic chemistry promises to impact the efficiency and sustainability of organic synthesis. Here we demonstrate that anodically generated hypervalent iodine intermediates effectively couple interfacial electron transfer with oxidative C–H/N–H coupling chemistry. The developed hypervalent iodine electrocatalysis is applicable in both intra- and intermolecular C–N bond-forming reactions. Available mechanistic data indicate that anodic oxidation of aryl iodides generates a transient I(II) intermediate that is critically stabilized by added acetate ions. This report represents the first example of metal-free hypervalent iodine electrocatalysis for C–H functionalization and provides mechanistic insight that we anticipate will contribute to the development of hypervalent iodine mediators for synthetic electrochemistry.
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