Pioglitazone and statins lower incidence of Parkinson disease in patients with diabetes mellitus

吡格列酮 医学 内科学 入射(几何) 糖尿病 危险系数 置信区间 噻唑烷二酮 比例危险模型 2型糖尿病 内分泌学 光学 物理
作者
Yu‐Hung Chang,Shih‐Jung Yen,Yo-Chen Chang,Wen‐Jeng Wu,Kun‐Der Lin
出处
期刊:European Journal of Neurology [Wiley]
卷期号:28 (2): 430-437 被引量:18
标识
DOI:10.1111/ene.14542
摘要

Background and purpose The pharmacologic effects of pioglitazone on the incidence of Parkinson disease (PD) are not clear. No study has examined the interaction between pioglitazone and statin treatment on prevention of PD. This study analyzed the associations between pioglitazone, statins, and the incidence of PD in patients with diabetes mellitus (DM) in Taiwan. Methods We used the National Health Insurance database from 1996 to 2013. DM and PD were diagnosed according to the International Classification of Diseases , Ninth Revision , Clinical Modification codes. We used the propensity score‐matching method to match the study groups. Cox regression analyses were employed to calculate the relative risk of the incidence of PD. Results There were 48 828 patients matched and categorized equally into the pioglitazone group and the non‐pioglitazone group. The number of PD patients in the pioglitazone group and the non‐pioglitazone group was 275 (1.1%) and 417 (1.7%), respectively. The pioglitazone group had a lower incidence of PD, with an adjusted hazard ratio (aHR) of 0.66 [95% confidence interval (CI): 0.57–0.78], and this benefit was dose‐dependent. Of note, as compared with either pioglitazone or statin treatment, our results first showed that the combination of pioglitazone and statins further lowered the risk of PD, with an aHR of 0.78 (95% CI: 0.64–0.94; P = 0.010). Conclusions Our study results suggested that pioglitazone could be a promising agent for reducing the incidence of PD in patients with DM, and works synergistically with statins.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
健康的皮带完成签到,获得积分10
3秒前
是十二呀完成签到,获得积分10
4秒前
隐形曼青应助Singularity采纳,获得10
6秒前
DK应助LIN采纳,获得10
6秒前
传奇3应助缥缈傥采纳,获得10
7秒前
9秒前
11秒前
哈哈哈完成签到 ,获得积分10
11秒前
紫霃完成签到,获得积分10
11秒前
香蕉觅云应助luo采纳,获得10
14秒前
bvh发布了新的文献求助10
15秒前
16秒前
小灰灰完成签到 ,获得积分10
18秒前
18秒前
缥缈傥发布了新的文献求助10
19秒前
20秒前
自信的九娘完成签到,获得积分10
20秒前
21秒前
22秒前
枯木完成签到 ,获得积分10
25秒前
26秒前
pip1412发布了新的文献求助10
26秒前
28秒前
weirdo发布了新的文献求助10
28秒前
29秒前
33秒前
向春山发布了新的文献求助10
34秒前
星辰大海应助迷路尔曼采纳,获得10
35秒前
小墨鱼完成签到,获得积分10
37秒前
38秒前
科研顺利发布了新的文献求助10
38秒前
麻了发布了新的文献求助20
40秒前
41秒前
赘婿应助cym666666采纳,获得10
41秒前
山丘应助科研通管家采纳,获得10
41秒前
41秒前
科研通AI2S应助科研通管家采纳,获得10
41秒前
爆米花应助科研通管家采纳,获得10
41秒前
科研通AI2S应助科研通管家采纳,获得10
41秒前
高分求助中
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3139135
求助须知:如何正确求助?哪些是违规求助? 2790050
关于积分的说明 7793436
捐赠科研通 2446426
什么是DOI,文献DOI怎么找? 1301124
科研通“疑难数据库(出版商)”最低求助积分说明 626106
版权声明 601102