已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Pioglitazone and statins lower incidence of Parkinson disease in patients with diabetes mellitus

吡格列酮 医学 内科学 入射(几何) 糖尿病 危险系数 置信区间 噻唑烷二酮 比例危险模型 2型糖尿病 内分泌学 光学 物理
作者
Yu‐Hung Chang,Shih‐Jung Yen,Yo-Chen Chang,Wen‐Jeng Wu,Kun‐Der Lin
出处
期刊:European Journal of Neurology [Wiley]
卷期号:28 (2): 430-437 被引量:18
标识
DOI:10.1111/ene.14542
摘要

Background and purpose The pharmacologic effects of pioglitazone on the incidence of Parkinson disease (PD) are not clear. No study has examined the interaction between pioglitazone and statin treatment on prevention of PD. This study analyzed the associations between pioglitazone, statins, and the incidence of PD in patients with diabetes mellitus (DM) in Taiwan. Methods We used the National Health Insurance database from 1996 to 2013. DM and PD were diagnosed according to the International Classification of Diseases , Ninth Revision , Clinical Modification codes. We used the propensity score‐matching method to match the study groups. Cox regression analyses were employed to calculate the relative risk of the incidence of PD. Results There were 48 828 patients matched and categorized equally into the pioglitazone group and the non‐pioglitazone group. The number of PD patients in the pioglitazone group and the non‐pioglitazone group was 275 (1.1%) and 417 (1.7%), respectively. The pioglitazone group had a lower incidence of PD, with an adjusted hazard ratio (aHR) of 0.66 [95% confidence interval (CI): 0.57–0.78], and this benefit was dose‐dependent. Of note, as compared with either pioglitazone or statin treatment, our results first showed that the combination of pioglitazone and statins further lowered the risk of PD, with an aHR of 0.78 (95% CI: 0.64–0.94; P = 0.010). Conclusions Our study results suggested that pioglitazone could be a promising agent for reducing the incidence of PD in patients with DM, and works synergistically with statins.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
7秒前
Toàn完成签到,获得积分10
8秒前
believe完成签到,获得积分10
10秒前
fg完成签到 ,获得积分10
10秒前
笑点低的怀莲完成签到,获得积分20
10秒前
11秒前
11秒前
13秒前
热心市民小红花给Strive的求助进行了留言
16秒前
悠悠发布了新的文献求助10
16秒前
fg发布了新的文献求助10
16秒前
19秒前
俊逸吐司完成签到 ,获得积分10
19秒前
小白兔完成签到 ,获得积分10
22秒前
23秒前
kami完成签到 ,获得积分10
26秒前
嗯哼应助科研通管家采纳,获得10
28秒前
CipherSage应助科研通管家采纳,获得10
28秒前
科研通AI2S应助科研通管家采纳,获得10
28秒前
嗯哼应助科研通管家采纳,获得20
28秒前
英姑应助科研通管家采纳,获得10
28秒前
田様应助科研通管家采纳,获得10
28秒前
嗯哼应助科研通管家采纳,获得20
28秒前
zqh应助科研通管家采纳,获得10
28秒前
29秒前
33秒前
33秒前
ggsr完成签到 ,获得积分10
35秒前
37秒前
现代访云发布了新的文献求助10
37秒前
李小伟完成签到,获得积分10
38秒前
我要发sci完成签到,获得积分20
39秒前
悠悠完成签到,获得积分10
39秒前
李小伟发布了新的文献求助10
42秒前
jasonjiang完成签到 ,获得积分10
43秒前
Dixxysus完成签到,获得积分20
46秒前
47秒前
48秒前
wdd完成签到 ,获得积分10
48秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3072420
求助须知:如何正确求助?哪些是违规求助? 2726230
关于积分的说明 7493301
捐赠科研通 2373930
什么是DOI,文献DOI怎么找? 1258827
科研通“疑难数据库(出版商)”最低求助积分说明 610392
版权声明 596967