已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix

腺癌 癌症研究 克拉斯 粘液癌 GNAS复合轨迹 生物 医学 STK11段 CDH1 CDKN2A 病理 癌症 基因 结直肠癌 遗传学 钙粘蛋白 细胞
作者
Eunhyang Park,Sang Wun Kim,Sunghoon Kim,Hyun-Soo Kim,Jung‐Yun Lee,Young Tae Kim,Nam Hoon Cho
出处
期刊:Modern Pathology [Elsevier BV]
卷期号:34 (3): 637-646 被引量:45
标识
DOI:10.1038/s41379-020-0614-0
摘要

Gastric-type mucinous carcinoma (GAS) is a recently established variant of endocervical mucinous adenocarcinoma that is characterized as being unrelated to HPV and having aggressive behavior and chemoresistance. GAS has a distinct morphology resembling nonneoplastic gastric glands or pancreaticobiliary adenocarcinoma, and their possible genetic similarity has been posed. In this study, next-generation sequencing was performed in 21 GAS cases using a customized panel including 94 cancer-associated genes. A total of 54 nonsynonymous somatic mutations were detected with an average mutation rate of 2.6 per lesion (range: 0–9). The most frequently mutated gene was TP53 (11/21, 52.4%), followed by STK11, HLA-B, PTPRS (4/21, 19.0%), FGFR4 (3/21, 14.3%), GNAS, BRCA2, ELF3, ERBB3, KMT2D, SLX4 (2/21, 9.5%), CDH1, EPCAM, KRAS, MLH1, RNF43, SNAI1, TWIST1, ZEB1, ZEB2, and so on (1/21, 4.8%). The mutated genes were mostly involved in signal transduction, DNA damage repair, and epithelial–mesenchymal transition (EMT). Correlation of TP53 mutation and p53 protein expression demonstrated that 31.3% with abnormal p53 expression harbored wild-type TP53. Compared to genetic features of gastric and pancreaticobiliary adenocarcinoma, TP53 mutations were frequent in both GAS and gastrointestinal adenocarcinoma. While KMT2D, ERBB3, and RNF43 mutations were shared between GAS and gastric adenocarcinoma, highly mutated genes in pancreatic ductal adenocarcinoma such as KRAS, SMAD4, and CDKN2A were rarely mutated in GAS. Of frequently mutated genes in cholangiocarcinoma, BAP1 and HLA-B were identified in GAS. Frequent EMT-related gene mutations suggested a possible role of EMT-related pathways in tumor dissemination and chemoresistance of GAS. In addition, GAS shared some genetic features with gastrointestinal adenocarcinoma. These findings provide a clue in understanding the biological basis of GAS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
活泼靖柏发布了新的文献求助10
刚刚
tuski发布了新的文献求助10
1秒前
苏幕遮发布了新的文献求助10
1秒前
陈阔完成签到 ,获得积分10
1秒前
JamesPei应助苹果绿采纳,获得10
1秒前
dada完成签到,获得积分10
3秒前
今日甜分超标完成签到,获得积分10
4秒前
4秒前
6秒前
量子星尘发布了新的文献求助20
8秒前
Lucas应助zhangxinxin采纳,获得20
9秒前
小蘑菇应助苏幕遮采纳,获得10
10秒前
zoerist发布了新的文献求助10
10秒前
北极星完成签到 ,获得积分10
10秒前
11秒前
xwq完成签到,获得积分10
11秒前
共享精神应助桐炫采纳,获得10
13秒前
14秒前
14秒前
活泼靖柏完成签到,获得积分20
14秒前
14秒前
lihaoyu发布了新的文献求助10
14秒前
高兴完成签到,获得积分10
15秒前
16秒前
天天快乐应助DAWONG采纳,获得10
16秒前
一枚咸鱼发布了新的文献求助20
17秒前
halo发布了新的文献求助10
17秒前
Derson完成签到,获得积分10
18秒前
18秒前
jkkm关注了科研通微信公众号
19秒前
LYPY发布了新的文献求助10
19秒前
彩色的荔枝完成签到 ,获得积分10
19秒前
20秒前
20秒前
大模型应助tuski采纳,获得10
21秒前
22秒前
ShengzhangLiu发布了新的文献求助10
23秒前
24秒前
25秒前
26秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Hidden Generalizations Phonological Opacity in Optimality Theory 500
translating meaning 500
Storie e culture della televisione 500
Selected research on camelid physiology and nutrition 500
《2023南京市住宿行业发展报告》 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4899596
求助须知:如何正确求助?哪些是违规求助? 4179969
关于积分的说明 12975865
捐赠科研通 3944037
什么是DOI,文献DOI怎么找? 2163607
邀请新用户注册赠送积分活动 1181857
关于科研通互助平台的介绍 1087598