透皮
角质层
抗菌剂
抗真菌
生物利用度
药品
抗感染药
药理学
药物输送
纳米技术
医学
材料科学
微生物学
生物
皮肤病科
病理
作者
Rezvan Jamaledin,Cynthia Kar Yung Yiu,Ehsan Nazarzadeh Zare,Li‐na Niu,Raffaele Vecchione,Guojun Chen,Zhen Gu,Franklin R. Tay,Pooyan Makvandi
标识
DOI:10.1002/adma.202002129
摘要
Abstract Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.
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