串扰
内质网
线粒体
细胞生物学
自噬
细胞器
生物
化学
细胞凋亡
生物化学
光学
物理
作者
Pabbala Veeresh,Harpreet Kaur,Deepaneeta Sarmah,Leela Mounica,Geetesh Verma,Vignesh Kotian,Radhika Kesharwani,Kiran Kalia,Anupom Borah,Xin Wang,Kunjan R. Dave,Anne‐Marie Rodriguez,Dileep R. Yavagal,Pallab Bhattacharya
摘要
The endoplasmic reticulum (ER) and mitochondria are fundamental organelles highly interconnected with a specialized set of proteins in cells. ER-mitochondrial interconnections form specific microdomains, called mitochondria-associated ER membranes, that have been found to play important roles in calcium signaling and lipid homeostasis, and more recently in mitochondrial dynamics, inflammation, and autophagy. It is not surprising that perturbations in ER-mitochondria connections can result in the progression of disease, especially neurological disorders; hence, their architecture and regulation are crucial in determining the fate of cells and disease. The molecular identity of the specialized proteins regulating ER-mitochondrial crosstalk remains unclear. Our discussion here describes the physical and functional crosstalk between these two dynamic organelles and emphasizes the outcome of altered ER-mitochondrial interconnections in neurological disorders.
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