Neutrophil diversity and plasticity in tumour progression and therapy

肿瘤微环境 髓样 免疫疗法 炎症 先天免疫系统 免疫学 血管生成 免疫系统 癌症免疫疗法 癌症研究 免疫抑制 癌症 生物 遗传学
作者
Sébastien Jaillon,Andrea Ponzetta,Diletta Di Mitri,Angela Santoni,Raffaella Bonecchi,Alberto Mantovani
出处
期刊:Nature Reviews Cancer [Springer Nature]
卷期号:20 (9): 485-503 被引量:727
标识
DOI:10.1038/s41568-020-0281-y
摘要

Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important component of the tumour microenvironment. Here, they can exert dual functions. TANs can be part of tumour-promoting inflammation by driving angiogenesis, extracellular matrix remodelling, metastasis and immunosuppression. Conversely, neutrophils can also mediate antitumour responses by direct killing of tumour cells and by participating in cellular networks that mediate antitumour resistance. Neutrophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment. Myeloid checkpoints as well as the tumour and tissue contexture shape neutrophil function in response to conventional therapies and immunotherapy. We surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches. This Review discusses the emerging dual role played by neutrophils in the tumour microenvironment as part of tumour-promoting inflammation, while also mediating antitumour immune responses, and suggests that neutrophil function could be manipulated in myeloid cell-based therapeutic approaches to improve patient outcomes.
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