Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears

增生性瘢痕 伤口愈合 血管内皮生长因子 结缔组织 CTGF公司 生长因子 血管生成 医学 转化生长因子 成纤维细胞生长因子受体1 病理 坏死 肿瘤坏死因子α 成纤维细胞生长因子 受体 内分泌学 癌症研究 内科学 免疫学 血管内皮生长因子受体
作者
Jun-Zeng,Tianyu Huang,Zhenzhen Wang,Yongfang Gong,Xing-Cun Liu,Xiao Ming Zhang,Xueying Huang
出处
期刊:International Immunopharmacology [Elsevier BV]
卷期号:90: 107200-107200 被引量:13
标识
DOI:10.1016/j.intimp.2020.107200
摘要

Hypertrophic scar (HS) is a dermal fibroproliferative disease that often occurs following abnormal wound healing. To date, there is no satisfied treatment strategies for improvement of scar formation with few side effects. The effects of gambogenic acid (GNA) on scar hypertrophy has not been studied previously. The present study was undertaken to find out the scar-reducing effects of GNA (0.48, 0.96 or 1.92 mg/ml) on skin wounds in rabbit ears. Scar evaluation index (SEI), collagen I (Col1) and collagen III (Col3), microvascular density (MVD), CD4+T cells and macrophages, vascular endothelial growth factor receptor 2 (VEGFR2), fibroblast growth factor receptor 1 (FGFR1), phospho-VEGFR 2 (p-VEGFR2) and p-FGFR1, interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1 and connective tissue growth factor (CTGF) in scar tissue were detected using various methods, respectively. Our data showed that GNA significantly reduced SEI, and the expression of Col1 and Col3 in scar tissue in a concentration-dependent manner. Also, it decreased MVD, the infiltration of CD4+T cells and macrophages, and the levels of VEGFR2, p-VEGFR2, FGFR1, p-FGFR1, TGF-β1, CTGF, IL-1β, IL-6, TNF-α, in addition to upregulated IL-10 in scar tissue. As a result, this study revealed that GNA reduced HS formation, which was associated with the inhibition of neoangiogenesis, local inflammatory response and growth factor expression in scar tissue during wound healing. These findings suggested that GNA may be considered as a preventive and therapeutic candidate for HS.
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