聚吡咯
声动力疗法
材料科学
医学
癌症研究
光热治疗
前药
化学
药理学
阿霉素
化疗
纳米技术
光动力疗法
内科学
聚合
聚合物
有机化学
复合材料
作者
Weijian Chen,Jing Wang,Liang Cheng,Wenxiang Du,Wei Wang,Wanwan Pan,Shuilai Qiu,Lei Song,Xiaopeng Ma,Yuan Hu
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2021-02-03
卷期号:4 (2): 1483-1492
被引量:16
标识
DOI:10.1021/acsabm.0c01370
摘要
Although a number of therapeutic strategies have been applied in cancer therapy, treatment for cancer metastasis is challenging due to unsatisfactory cure rate and easy cancer recurrence. In our work, nanocomposites (NCs) based on polypyrrole-coated mesoporous TiO2 with a suitable size are prepared through a modified soft-templating strategy, which integrates double prodrugs (doxorubicin (DOX) prodrug and aspirin prodrug) with superior drug loading capacity. Under external stimulation of near-infrared (NIR) and ultrasound (US), the prepared nanocomposites have an excellent photothermal conversion efficiency (over 50.8%) and a satisfactory sonodynamic therapeutic effect, and simultaneous prodrug activation and drug release occur rapidly under external stimulation. Through intravenous injection, the tumor area can be clearly seen through thermal imaging, benefiting from the enhanced permeability and retention (EPR) effect. Through synergistic therapy, cancer cell toxicity and the tumor inhibition effect are significantly enhanced. Moreover, downregulated inflammatory factors also reduce the risk of cancer recurrence. In general, the designed NCs provide a potential alternative for synergistic therapy as well as downregulation of inflammatory cytokines.
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