高粱
生物
驯化
同步
基因组学
比较基因组学
人口
遗传变异
遗传学
植物遗传学
农学
高粱双色
进化生物学
基因
基因组
生物技术
人口学
社会学
作者
Roberto Lozano,Élodie Gazave,J. Santos,Markus G Stetter,Ravi Valluru,Nonoy Bandillo,Samuel B. Fernandes,Patrick J. Brown,Nadia Shakoor,Todd C. Mockler,Elizabeth Cooper,M. Taylor Perkins,Edward S. Buckler,Jeffrey Ross‐Ibarra,Michael A. Gore
出处
期刊:Nature plants
[Springer Nature]
日期:2021-01-15
卷期号:7 (1): 17-24
被引量:68
标识
DOI:10.1038/s41477-020-00834-5
摘要
Sorghum and maize share a close evolutionary history that can be explored through comparative genomics1,2. To perform a large-scale comparison of the genomic variation between these two species, we analysed ~13 million variants identified from whole-genome resequencing of 499 sorghum lines together with 25 million variants previously identified in 1,218 maize lines. Deleterious mutations in both species were prevalent in pericentromeric regions, enriched in non-syntenic genes and present at low allele frequencies. A comparison of deleterious burden between sorghum and maize revealed that sorghum, in contrast to maize, departed from the domestication-cost hypothesis that predicts a higher deleterious burden among domesticates compared with wild lines. Additionally, sorghum and maize population genetic summary statistics were used to predict a gene deleterious index with an accuracy greater than 0.5. This research represents a key step towards understanding the evolutionary dynamics of deleterious variants in sorghum and provides a comparative genomics framework to start prioritizing these variants for removal through genome editing and breeding.
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