检测点注意事项
生物传感器
小型化
注意事项
纳米技术
计算机科学
系统工程
工程类
医学
材料科学
护理部
免疫学
作者
Dan Liu,Junxia Wang,Lingling Wu,Yishun Huang,Yuqian Zhang,Mingyang Zhu,Yang Wang,Zhi Zhu,Chaoyong Yang
标识
DOI:10.1016/j.trac.2019.115701
摘要
The popularization of point-of-care (POC) testing is of great importance in healthcare diagnostics and other fields in the developing world, especially in resource-limited settings. To date, there are still great challenges in the development of simple, quick, affordable, yet highly effective and selective biosensors for POC testing. To meet the increasing need for POC testing, researchers need to consider biosensor miniaturization. In this review, we focus on recent advances in miniaturized biosensors for POC testing. We first review the miniaturization strategies, including handheld instruments and microfluidics-assisted miniaturized biosensing systems. Recent progress in recognition biosensing interactions for miniaturized biosensing systems is then summarized. We further describe how POC testing applications can be realized based on developments in integration, automation and multiplexing. Finally, the future prospects and remaining challenges of miniaturized biosensors for POC testing are discussed.
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