SYNTHESIS AND ANTIOXIDANT EVALUATION OF 3-BROMO-FLAVONE

Objective: The objective of the study was to obtain a flavone derivative compound through N-bromosuccinimide (NBS) reducing the reaction. Theantioxidant activity of the synthetic compound was then assayed by the 2,2-diphenyl-1-picrylhydrazyl method.Methods: Chalcone (3 mmol) as intermediate precursor was suspended with dimethyl sulfoxide and reacted with NBS (3 mmol), stirred at roomtemperature for 25 min and diluted in cold water. The synthesis of flavone derivatives resulted in yellow crystalline powder, freely soluble in methanoland ethanol, renamed 60% with a melting point of 87.7°C. Detection by thin-layer chromatography using hexane:chloroform (2:1) showed single spotwith Rf = 0.38 which is different from the Rf value of the starting compound (chalcone, 0.66 and 0.78).Results: The results of the characterization of the synthesized compound using ultraviolet-visible and Fourier transform-infared showed the groupcharacteristic containing C=C (1604.77 and 1639.49 cm-1), C=O (1681.93 cm-1), C-O-C (1242.16 cm-1), Ar-H (3032.1 and 3062.96 cm-1), and C-Br(663.51 cm-1) at maximum absorption of wavelength 253 nm.Conclusion: The synthesis of flavone using NBS resulted in 3-bromo-flavone with a weak antioxidant activity.