化学
催化作用
分子内力
弗里德尔-克拉夫茨反应
组合化学
键裂
选择性
反应条件
戒指(化学)
劈理(地质)
广谱
有机化学
断裂(地质)
工程类
岩土工程
作者
Arup K. Kabi,Raghuram Gujjarappa,Nagaraju Vodnala,Dhananjaya Kaldhi,Ujjawal Tyagi,K. Mukherjee,Chandi C. Malakar
标识
DOI:10.1016/j.tetlet.2020.152535
摘要
A simple and cost-effective 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)-mediated protocol for the synthesis of β-oxo amides has been described by using amines and β-keto esters as substrates. The reaction conditions were found to be highly efficient towards the cleavage of CO bond and consequent formation of the products in excellent yields and selectivity. The obtained β-oxo amides were further transformed in to the synthetically useful 2‑quinolinones via intramolecular Friedel-Craft type cyclization of aromatic ring using ferrites as a recyclable catalyst. A spectrum of substrates bearing broad range of functional groups were well tolerated under the reaction conditions. The proposed mechanistic pathways were substantially verified by literature and mass-spectroscopic evidences.
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