Mechanisms of chemotherapy-induced ovarian damage and fertility preservation

Chemotherapy can induce ovarian damage while treating malignant tumor, which causes amenorrhea and infertility. The understanding of the mechanisms of chemotherapy-induced ovarian damage may lead to targeted treatments to preserve fertility. It has been proved that there are many methods and medicines to protect ovarian function and realize the preservation of fertility. This article reviews the mechanisms of chemotherapy-induced ovarian damage and the progress of fertility preservation. Key words: Chemotherapy; Ovarian function; Fertility preservation