The role of CCL8 in immune regulation of diseases

Monocyte chemoattractant protein 2 (MCP-2), also named CCL8, is a member of the CC chemokine family and it could attract monocytes, T lymphocytes, eosinophils, and basophils, NK cell and DC cell through recognizing several receptors including CCR1, CCR2, CCR3, CCR5.It play an important role in regulation of immunity in inflammation response, anti-tumor immunity and acute graft versus host disease (aGVHD). It is impostant to makes a summary on the biological characteristics of CCL8 and the development of the role of CCL8 in immune regulation of diseases. Key words: Immunity; Chemokine; CCL8