海马旁回
梭状回
边缘叶
功能磁共振成像
神经科学
静息状态功能磁共振成像
扁桃形结构
海马体
心理学
舌回
颞上回
意识的神经相关物
脑回
神经心理学
梭形面区
齿状回
医学
听力学
颞叶
认知
面部知觉
癫痫
感知
作者
Peng Zhang,Guowei Wu,Feng Yu,Liu Yang,Meng‐yi Li,Zheng Wang,Heyu Ding,Xiao-Shuai Li,Hao Wang,Mei Jin,Zhengyu Zhang,Peng Zhao,Jing Li,Zhenghan Yang,Han Lv,Zhong‐tao Zhang
出处
期刊:Obesity
[Wiley]
日期:2020-06-08
卷期号:28 (7): 1283-1291
被引量:19
摘要
Objective This study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior. Methods A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0‐T MRI. Amplitude of low‐frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting‐state fMRI and Resting‐State fMRI Data Analysis Toolkit (REST). Results The group with obesity showed increased amplitude of low‐frequency values in left fusiform gyrus/amygdala, inferior temporal gyrus (ITG), hippocampus/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus/amygdala and left ITG, right caudate and left fusiform gyrus/amygdala, and right caudate and left hippocampus/parahippocampal gyrus. Dutch Eating Behavior Questionnaire‐Emotional scores were positively correlated with FC between left hippocampus/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus/amygdala and left ITG. Conclusions The study indicated the reorganized neural network presented as a bilateral cross‐regulation pattern across hemispheres between reward and various appetite‐related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.
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