Hypoxia-inducible factor-l attributing to tumor angiogenesis

Hypoxia-inducible factor-1 ( HIF-1 ) is one of the most important transcriptional factors which regulate the transcription of vascular endothelial growth factor ( VEGF ), HIF-1 plays a critical role in tumor angiogenesis and metastasis. The transcriptional regulation role for HIF-1 in tumor angiogenesis is closely related to its molecular structure,biological character and molecular mechanism and signaling pathways. Key words: Neoplasms; Hypoxia-inducible factor-l; Vascular endothelial growth factors; Angiopoietins