Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

褪黑素 偏头痛 昼夜节律 失眠症 黑暗疗法 医学 睡眠(系统调用) 类阿片 内科学 心理学 内分泌学 药理学 受体 计算机科学 操作系统
作者
Tae-Jin Song,Byung‐Su Kim,Min Kyung Chu
出处
期刊:Progress in Brain Research 卷期号:: 343-369 被引量:12
标识
DOI:10.1016/bs.pbr.2020.05.014
摘要

Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
沧海一笑发布了新的文献求助10
3秒前
好好完成签到,获得积分10
3秒前
zhaohu47完成签到,获得积分10
3秒前
4秒前
4秒前
千秋入画发布了新的文献求助10
4秒前
7秒前
kerri完成签到,获得积分20
8秒前
9秒前
lewong完成签到,获得积分10
9秒前
Macgonal发布了新的文献求助30
10秒前
11秒前
11秒前
1128完成签到 ,获得积分10
12秒前
千秋入画完成签到,获得积分10
12秒前
汉堡包应助科研通管家采纳,获得10
12秒前
领导范儿应助科研通管家采纳,获得10
12秒前
香蕉觅云应助科研通管家采纳,获得10
12秒前
Hello应助科研通管家采纳,获得10
13秒前
彭于晏应助科研通管家采纳,获得10
13秒前
CWNU_HAN应助科研通管家采纳,获得30
13秒前
香蕉觅云应助科研通管家采纳,获得10
13秒前
13秒前
打打应助科研通管家采纳,获得10
13秒前
情怀应助科研通管家采纳,获得10
13秒前
不配.应助科研通管家采纳,获得30
13秒前
NexusExplorer应助科研通管家采纳,获得10
13秒前
鄒鄒应助科研通管家采纳,获得200
13秒前
赘婿应助科研通管家采纳,获得10
13秒前
李健应助科研通管家采纳,获得10
13秒前
斯文败类应助科研通管家采纳,获得10
13秒前
美好乐松应助科研通管家采纳,获得10
13秒前
华仔应助科研通管家采纳,获得10
14秒前
科研通AI2S应助科研通管家采纳,获得10
14秒前
CipherSage应助科研通管家采纳,获得30
14秒前
丘比特应助科研通管家采纳,获得10
14秒前
14秒前
14秒前
14秒前
14秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189389
求助须知:如何正确求助?哪些是违规求助? 2838764
关于积分的说明 8021434
捐赠科研通 2501634
什么是DOI,文献DOI怎么找? 1335889
科研通“疑难数据库(出版商)”最低求助积分说明 637729
邀请新用户注册赠送积分活动 605784