褪黑素
偏头痛
昼夜节律
失眠症
黑暗疗法
医学
睡眠(系统调用)
类阿片
内科学
心理学
内分泌学
药理学
受体
计算机科学
操作系统
作者
Tae-Jin Song,Byung‐Su Kim,Min Kyung Chu
出处
期刊:Progress in Brain Research
日期:2020-01-01
卷期号:: 343-369
被引量:12
标识
DOI:10.1016/bs.pbr.2020.05.014
摘要
Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.
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